Interleukin 6 (rs1800795) and pentraxin 3 (rs2305619) polymorphisms-association with inflammation and all-cause mortality in end-stage-renal disease patients on dialysis

Abstract Chronic inflammation plays an important role in the progression and outcome of chronic kidney disease (CKD). The circulating levels inflammatory biomarkers interleukin 6 (IL6) pentraxin 3 (PTX3) are enhanced CKD patients, associated with higher risk for cardiovascular events, major cause death patients. Our aim was to study how specific polymorphisms IL6 PTX3 encoding genes affect response end-stage renal (ESRD) patients on dialysis. Methodology included analysis two single nucleotide (SNP), namely (rs1800795) polymorphism promoter region (-174G > C), (rs2305619) intron 1 (+ 281A G), which were analyzed ESRD dialysis a group heathy individuals. allelic frequencies, genotype distribution their association markers C-reactive protein (CRP), IL6, growth differentiation factor 15 (GDF15) PTX3, determined Events recorded along one year, assess studied SNPs all-cause mortality biomarkers, Results showed that frequencies control similar agreement other European reports. For polymorphism, we found trend towards high-sensitivity (hs) CRP, homozygous genotypes; CC also highest GDF15. rate after 1-year follow-up 10.4%. ( SNP) deceased carrying this hsCRP. Regarding SNP, AA linked response, showing values hsCRP IL6. Nevertheless, had no significant impact rate. In conclusion, both seem modulate may, therefore, be determinant patients’ outcome. data highlights importance research genetic variants that, although less frequent, may have biological value.